预凝固硫酸钙二水合物/羟基磷灰石骨移植增量材料在兔腰椎后外侧融合模型中的评估Evaluation of a Pre-set Calcium Sulphate Dihydrate/Hydroxyapatite Bone Graft Extender in a Rabbit Posterolateral Spinal Fusion Model
瑞典隆德大学与立陶宛健康科学大学在 26 只兔的 L4–L5 后外侧腰椎融合模型中，评估 XERAFUSE 预凝固硫酸钙二水合物/羟基磷灰石颗粒按 1:1 与自体骨合用作为骨移植增量材料的效果。离体 micro-CT（30 µm 体素）在 Dragonfly 3D World 1.14.4.1 中做定量形态学和三维可视化：先用 1900–6500 HU 全局阈值分出矿化组织，再用 Dragonfly 的 Segmentation Wizard（训练分类器）把融合区分为骨组织和残余材料，两名评估者独立标注，结果差异小于 15%，并用「Bone」预设生成三维重建。12 周时增量材料组骨体积 850 ± 68.4 mm³，显著高于单用自体骨组的 468.9 ± 105.3 mm³；融合块中材料占比从 4 周的 41.3% 降到 12 周的 28.1%。作者致谢 Comet Technologies（加拿大）提供 Dragonfly 非商业许可。Lund University (Sweden) and the Lithuanian University of Health Sciences evaluated XERAFUSE pre-set calcium sulphate dihydrate/hydroxyapatite granules, co-implanted 1:1 with autograft as a bone graft extender, in an L4–L5 posterolateral lumbar fusion model in 26 rabbits. Ex vivo micro-CT (30 µm voxels) was analyzed and visualized in Dragonfly 3D World 1.14.4.1: a 1900–6500 HU global threshold isolated mineralized tissue, then Dragonfly's Segmentation Wizard (a trained classifier) separated the fusion mass into bone and residual biomaterial, with two independent evaluators agreeing within 15%, and 3D reconstructions were made with the "Bone" preset. At 12 weeks bone volume in the extender group was 850 ± 68.4 mm³ versus 468.9 ± 105.3 mm³ with autograft alone, and the material fraction of the fusion mass fell from 41.3% at 4 weeks to 28.1% at 12 weeks. The authors thank Comet Technologies (Canada) for a non-commercial Dragonfly license.